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    SPT7 SAGA histone acetyltransferase complex subunit SPT7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPT7
    Official Full Name
    SAGA histone acetyltransferase complex subunit SPT7
    Primary source
    SGD:S000000285
    Locus tag
    YBR081C
    See related
    AllianceGenome:SGD:S000000285; FungiDB:YBR081C; VEuPathDB:YBR081C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GIT2
    Summary
    Enables structural molecule activity. Involved in chromatin organization; conjugation with cellular fusion; and protein-containing complex assembly. Located in mitochondrion. Part of SAGA complex and SLIK (SAGA-like) complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPT7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (401253..405251, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit a Neighboring gene AAA family ATPase SEC18 Neighboring gene tRNA-Arg Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo. Gansheroff LJ, et al. Genetics, 1995 Feb. PMID 7713415, Free PMC Article
    2. Involvement of Spt7p in vacuolar polyphosphate level of Saccharomyces cerevisiae. Nishimura K, et al. Biochem Biophys Res Commun, 1999 Apr 21. PMID 10208869
    3. Cross-talk between histone H3 tails produces cooperative nucleosome acetylation. Li S, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 19004784, Free PMC Article
    4. Transcription of some PHO genes in Saccharomyces cerevisiae is regulated by spt7p. Nishimura K, et al. Yeast, 1999 Dec. PMID 10590460
    5. Three genes are required for trans-activation of Ty transcription in yeast. Winston F, et al. Genetics, 1987 Apr. PMID 3034719, Free PMC Article

    See all (177) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAGA-CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity.
      Title: SAGA-CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity.
    2. SAGA-TBP binding involves a network of interactions between subunits Spt3, Spt8, Spt20, and Spt7.
      Title: Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.
    3. truncation of Spt7 occurs early in the biosynthesis of distinct Spt7 containing complexes rather than being a dynamic process linked to the action of the SAGA complex in transcriptional regulation
      Title: C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SAGA histone acetyltransferase complex subunit SPT7
    NP_009637.1
    • Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      401253..405251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178429.1 → NP_009637.1  TPA: SAGA histone acetyltransferase complex subunit SPT7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ80, P35177
      UniProtKB/TrEMBL
      C7GQJ4, N1P834
      Conserved Domains (1) summary
      COG5076
      Location:282 → 680
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35177.1

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