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    RIB1 GTP cyclohydrolase II [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIB1
    Official Full Name
    GTP cyclohydrolase II
    Primary source
    SGD:S000000129
    Locus tag
    YBL033C
    See related
    AllianceGenome:SGD:S000000129; FungiDB:YBL033C; VEuPathDB:YBL033C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclohydrolase activity. Involved in riboflavin biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RIB1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (158656..159693, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase alpha subunit POL12 Neighboring gene Stu1p Neighboring gene Hek2p Neighboring gene She1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast. Anam K, et al. Sci Rep, 2020 Apr 7. PMID 32265460, Free PMC Article
    2. Mapping of the RIB1 and RIB7 genes involved in the biosynthesis of riboflavin in Saccharomyces cerevisiae. Buitrago MJ, et al. Yeast, 1993 Oct. PMID 8256517
    3. Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 . Oltmanns O, et al. J Bacteriol, 1972 Jun. PMID 4555411, Free PMC Article
    4. Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis. Richter G, et al. J Bacteriol, 1997 Mar. PMID 9068650, Free PMC Article
    5. Genetical classification of riboflavineless mutants of Saccharomyces cerevisiae. Oltmanns O, et al. Antonie Van Leeuwenhoek, 1969 Jun. PMID 5312045

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast.
      Title: A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP cyclohydrolase II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclohydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    GTP cyclohydrolase II
    NP_009520.1
    • GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      158656..159693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178273.1 → NP_009520.1  TPA: GTP cyclohydrolase II [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPW6, P38066
      UniProtKB/TrEMBL
      A6ZKR4, B3LNH1, B5VDV0, C7GNC9, C8Z3W3, G2W8X5, N1P9Q7
      Conserved Domains (1) summary
      TIGR00505
      Location:85 → 309
      ribA; GTP cyclohydrolase II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38066.2

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