CBC2 nuclear cap-binding protein subunit CBC2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CBC2
Official Full Name: nuclear cap-binding protein subunit CBC2
Primary source: SGD:S000006099
Locus tag: YPL178W
See related: AllianceGenome:SGD:S000006099; FungiDB:YPL178W; VEuPathDB:YPL178W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CBP20; MUD13; SAE1
Summary: Enables RNA cap binding activity. Involved in mRNA splicing, via spliceosome. Part of commitment complex and nuclear cap binding activity complex. Orthologous to several human genes including NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CBC2 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (212158..212784)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Npl3 and Cbc2 may function in maintaining telomere stability perhaps as telomere capping proteins.
Title: Yeast hnRNP-related proteins contribute to the maintenance of telomeres.
CBC2 is a governor of gene-specific pre-mRNA splicing during meiotic development.
Title: Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA cap binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA cis splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of commitment complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear cap binding complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cap binding complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear cap binding complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear cap-binding protein subunit CBC2

NP_015147.1

Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

212158..212784

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183992.1 → NP_015147.1 TPA: nuclear cap-binding protein subunit CBC2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015147.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3J0, Q08920

UniProtKB/TrEMBL

A6ZW75, B3LKQ0, B5VSZ4, C7GJC7, C8ZIK0, G2WP04, N1NY09

Conserved Domains (2) summary

COG0724
Location:1 → 159

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12240
Location:48 → 125

RRM_NCBP2; RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins