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    MAG2 Mag2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851147, updated on 17-Dec-2024

    Summary

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    Official Symbol
    MAG2
    Official Full Name
    Mag2p
    Primary source
    SGD:S000004419
    Locus tag
    YLR427W
    See related
    AllianceGenome:SGD:S000004419; FungiDB:YLR427W; VEuPathDB:YLR427W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin protein ligase activity. Involved in nonfunctional rRNA decay and protein monoubiquitination. Located in cytoplasm. Is active in cytosolic ribosome. Orthologous to human RNF10 (ring finger protein 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAG2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (988428..990440)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rho family guanine nucleotide exchange factor TUS1 Neighboring gene Tda5p Neighboring gene Crn1p Neighboring gene DNA/RNA helicase SEN1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic approach for validating the ubiquitinated proteome. Seyfried NT, et al. Anal Chem, 2008 Jun 1. PMID 18433149, Free PMC Article
    2. Sequential Ubiquitination of Ribosomal Protein uS3 Triggers the Degradation of Non-functional 18S rRNA. Sugiyama T, et al. Cell Rep, 2019 Mar 19. PMID 30893611
    3. Mechanisms of patulin toxicity under conditions that inhibit yeast growth. Iwahashi Y, et al. J Agric Food Chem, 2006 Mar 8. PMID 16506856
    4. Predicting protein functions from redundancies in large-scale protein interaction networks. Samanta MP, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14566057, Free PMC Article
    5. A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. Choi J, et al. PLoS One, 2017. PMID 28520786, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nonfunctional rRNA decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mag2p
    NP_013531.3
    • Cytoplasmic RING-finger type E3 ubiquitin ligase; involved in monoubiquitination of Rps3p, a 40S subunit from decoding-defective ribosomes, leading to Fap1p-mediated K63-linked polyubiquitination, followed by dissociation of non-functional 80S ribosomes and non-functional rRNA decay (NRD) of 18S rRNA; ubiquitinated; induced in response to mycotoxin patulin; predicted to be involved in repair of alkylated DNA due to interaction with MAG1; similar to the human ring finger motif protein RNF10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      988428..990440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182315.3 → NP_013531.3  TPA: Mag2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013531.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ63, Q06436
      UniProtKB/TrEMBL
      A7A1U8, C8ZE35, N1NZW7
      Conserved Domains (1) summary
      cd16536
      Location:195 → 249
      RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06436.1

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