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    GMC2 Gmc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GMC2
    Official Full Name
    Gmc2p
    Primary source
    SGD:S000004437
    Locus tag
    YLR445W
    See related
    AllianceGenome:SGD:S000004437; FungiDB:YLR445W; VEuPathDB:YLR445W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein sumoylation; reciprocal meiotic recombination; and synaptonemal complex organization. Located in peroxisome and synaptonemal complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GMC2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (1024189..1024837)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene chromatin-silencing protein SIR3 Neighboring gene Ecm7p Neighboring gene hexokinase Neighboring gene H(+)-transporting V0 sector ATPase subunit d

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation. Lee MS, et al. Nucleic Acids Res, 2021 Jul 21. PMID 34197600, Free PMC Article
    2. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Roberts CJ, et al. Science, 2000 Feb 4. PMID 10657304
    3. The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Williams RM, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370439, Free PMC Article
    4. The synaptonemal complex is assembled by a polySUMOylation-driven feedback mechanism in yeast. Leung WK, et al. J Cell Biol, 2015 Nov 23. PMID 26598615, Free PMC Article
    5. The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. Humphryes N, et al. PLoS Genet, 2013. PMID 23326245, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation.
      Title: The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation.
    2. We propose that the Ecm11-Gmc2 complex facilitates the assembly of Zip1 and that SUMOylation of Ecm11 is critical for ensuring chromosomal assembly of Zip1, thus suppressing polycomplex formation.
      Title: The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gmc2p
    NP_013550.4
    • Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor; also detected in peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1024189..1024837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182333.3 → NP_013550.4  TPA: Gmc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013550.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ79, Q06201
      UniProtKB/TrEMBL
      A7A1W4, G2WJQ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06201.2

    Gene LinkOut

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