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    Gpr83 G protein-coupled receptor 83 [ Mus musculus (house mouse) ]

    Gene ID: 14608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr83provided by MGI
    Official Full Name
    G protein-coupled receptor 83provided by MGI
    Primary source
    MGI:MGI:95712
    See related
    Ensembl:ENSMUSG00000031932 AllianceGenome:MGI:95712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gir; RP39; RP82; Gpr72; RP105
    Summary
    Enables neuropeptide receptor activity. Involved in feeding behavior; neuropeptide signaling pathway; and phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within response to glucocorticoid. Located in non-motile cilium and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and pectoralis. Orthologous to human GPR83 (G protein-coupled receptor 83). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 4.8), frontal lobe adult (RPKM 3.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr83 in Genome Data Viewer
    Location:
    9 A2; 9 4.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14771038..14782085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14859880..14870789)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23360 Neighboring gene MRE11A homolog A, double strand break repair nuclease Neighboring gene macrophage migration inhibitory factor, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_23361 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene STARR-seq mESC enhancer starr_23362 Neighboring gene coenzyme Q10 homolog B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. Toms C, et al. Immunology, 2008 Nov. PMID 18479351, Free PMC Article
    2. Gpr83 Tunes Nociceptor Function, Controlling Pain. Kim Y, et al. Neurotherapeutics, 2023 Jan. PMID 36352334, Free PMC Article
    3. PEN Receptor GPR83 in Anxiety-Like Behaviors: Differential Regulation in Global vs Amygdalar Knockdown. Fakira AK, et al. Front Neurosci, 2021. PMID 34512237, Free PMC Article
    4. The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences. Fakira AK, et al. Neuropharmacology, 2019 Oct. PMID 31199956, Free PMC Article
    5. Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin. Dubins JS, et al. Metabolism, 2012 Oct. PMID 22560055, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpr83 Tunes Nociceptor Function, Controlling Pain.
      Title: Gpr83 Tunes Nociceptor Function, Controlling Pain.
    2. findings detect GPR83 expression in the reward-pathway, and show its involvement in dopamine release and morphine reward-learning.
      Title: The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences.
    3. this study identified a receptor for PEN in mouse hypothalamus and Neuro2A cellsit. It is GPR83.
      Title: Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.
    4. Data indicate that the extracellular portion of G-protein coupled receptor 83 (GPR83) has a strong regulatory function on this receptor.
      Title: The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist.
    5. Gpr83 modulates ghrelin action and Gpr83 regulates systemic metabolism through other ghrelin-independent pathways.
      Title: The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
    6. GIR -/- mice show increased preference for sucrose, delayed acquisition of spatial learning and insensitivity to the anxiogenic effects of restraint stress.
      Title: Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice.
    7. GPR83 may participate in central thermoregulation and the central control of circulating adiponectin.
      Title: Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin.
    8. These results demonstrate that GPR83 is dispensable for Treg-cell development and function.
      Title: G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells.
    9. Gpr83 is critically involved in the peripheral conversion of Foxp3-negative to Foxp3-expressing regulatory T cells in vivo.
      Title: G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 83
    Names
    glucocorticoid-induced receptor
    probable G-protein coupled receptor 83

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310734.1 → NP_001297663.1  G-protein coupled receptor 83 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001297663.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC136743, AK030359, AK035356, AK041527
      Consensus CDS
      CCDS80959.1
      UniProtKB/TrEMBL
      Q544C4
      Related
      ENSMUSP00000111287.3, ENSMUST00000115624.3
      Conserved Domains (1) summary
      pfam00001
      Location:88 → 303
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_010287.3 → NP_034417.1  G-protein coupled receptor 83 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK030359, AK035356, AK041527, AK081276
      Consensus CDS
      CCDS22829.1
      UniProtKB/Swiss-Prot
      P30731, Q542Q9, Q544C4
      UniProtKB/TrEMBL
      Q9EPJ7
      Related
      ENSMUSP00000034408.6, ENSMUST00000034408.12
      Conserved Domains (2) summary
      pfam00001
      Location:88 → 345
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:78 → 225
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      14771038..14782085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244058.2 → XP_030099918.1  G-protein coupled receptor 83 isoform X1

      UniProtKB/TrEMBL
      Q9EPJ7
      Conserved Domains (1) summary
      cd15389
      Location:72 → 413
      7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_006510017.4 → XP_006510080.1  G-protein coupled receptor 83 isoform X2

      UniProtKB/TrEMBL
      Q9EPJ7
      Conserved Domains (1) summary
      cd15389
      Location:72 → 376
      7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30731.2 GenPept UniProtKB/Swiss-Prot:P30731

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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