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    Dennd2a DENN domain containing 2A [ Mus musculus (house mouse) ]

    Gene ID: 209773, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dennd2aprovided by MGI
    Official Full Name
    DENN domain containing 2Aprovided by MGI
    Primary source
    MGI:MGI:2444961
    See related
    Ensembl:ENSMUSG00000038456 AllianceGenome:MGI:2444961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1277; C130031G22; B930096L08Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in actin cytoskeleton. Is expressed in cerebral cortex ventricular layer and head. Orthologous to human DENND2A (DENN domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 15.8), limb E14.5 (RPKM 12.4) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dennd2a in Genome Data Viewer
    Location:
    6 B1; 6 18.26 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39439308..39535067, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39462374..39558145, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene makorin, ring finger protein, 1 Neighboring gene STARR-seq mESC enhancer starr_15650 Neighboring gene predicted gene 10244 Neighboring gene predicted gene, 25402 Neighboring gene STARR-seq mESC enhancer starr_15653 Neighboring gene STARR-seq mESC enhancer starr_15655 Neighboring gene predicted gene, 52860 Neighboring gene STARR-seq mESC enhancer starr_15661 Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321 Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DENN domain-containing protein 2A
    Names
    DENN/MADD domain containing 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418005.1NP_001404934.1  DENN domain-containing protein 2A isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624
      UniProtKB/Swiss-Prot
      Q3TJU2, Q3TUG3, Q3UXA3, Q8C4S8
      UniProtKB/TrEMBL
      B7ZP28
    2. NM_001418006.1NP_001404935.1  DENN domain-containing protein 2A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624
      UniProtKB/TrEMBL
      B7ZP28
    3. NM_001418007.1NP_001404936.1  DENN domain-containing protein 2A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624
      UniProtKB/TrEMBL
      B7ZP28
    4. NM_001418008.1NP_001404937.1  DENN domain-containing protein 2A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624
    5. NM_172477.5NP_766065.1  DENN domain-containing protein 2A isoform a

      See identical proteins and their annotated locations for NP_766065.1

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC153624
      Consensus CDS
      CCDS20023.1
      UniProtKB/Swiss-Prot
      Q3TJU2, Q3TUG3, Q3UXA3, Q8C4S8
      UniProtKB/TrEMBL
      B7ZP28
      Related
      ENSMUSP00000045367.4, ENSMUST00000036877.10
      Conserved Domains (3) summary
      smart00801
      Location:895953
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:554646
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:653809
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39439308..39535067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321485.3XP_017176974.1  DENN domain-containing protein 2A isoform X4

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:9571015
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:616708
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:715871
      DENN; DENN (AEX-3) domain
    2. XM_011241272.4XP_011239574.2  DENN domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:9901048
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:649741
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:748904
      DENN; DENN (AEX-3) domain
    3. XM_011241273.4XP_011239575.2  DENN domain-containing protein 2A isoform X5

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:924982
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:583675
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:682838
      DENN; DENN (AEX-3) domain
    4. XM_017321484.3XP_017176973.1  DENN domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:9911049
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:650742
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:749905
      DENN; DENN (AEX-3) domain
    5. XM_006505836.5XP_006505899.1  DENN domain-containing protein 2A isoform X3

      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:9631021
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:622714
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:721877
      DENN; DENN (AEX-3) domain
    6. XM_030255296.2XP_030111156.1  DENN domain-containing protein 2A isoform X6

      UniProtKB/Swiss-Prot
      Q3TJU2, Q3TUG3, Q3UXA3, Q8C4S8
      UniProtKB/TrEMBL
      B7ZP28
      Conserved Domains (3) summary
      smart00801
      Location:895953
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:554646
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:653809
      DENN; DENN (AEX-3) domain