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    Cyp4f14 cytochrome P450, family 4, subfamily f, polypeptide 14 [ Mus musculus (house mouse) ]

    Gene ID: 64385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4f14provided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 14provided by MGI
    Primary source
    MGI:MGI:1927669
    See related
    Ensembl:ENSMUSG00000024292 AllianceGenome:MGI:1927669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cyp4f-14; 1300014O15Rik
    Summary
    Predicted to enable arachidonate binding activity; heme binding activity; and monooxygenase activity. Predicted to be involved in leukotriene B4 catabolic process and omega-hydroxylase P450 pathway. Predicted to be located in apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Is expressed in liver; nervous system; and testis. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 321.3), small intestine adult (RPKM 298.0) and 3 other tissues See more
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    Genomic context

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    See Cyp4f14 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33122331..33136353, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32903357..32917376, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 50050 Neighboring gene STARR-seq mESC enhancer starr_42396 Neighboring gene zinc finger protein 870 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42397 Neighboring gene zinc finger protein 870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33028261-33028519 Neighboring gene STARR-seq mESC enhancer starr_42399 Neighboring gene STARR-seq mESC enhancer starr_42400 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33084248-33084483 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 41 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7516

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism. Bardowell SA, et al. J Biol Chem, 2012 Jul 27. PMID 22665481, Free PMC Article
    2. Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. Kikuta Y, et al. Arch Biochem Biophys, 2000 Nov 15. PMID 11185557
    3. Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation. Sehgal N, et al. Biochem Pharmacol, 2011 Jul 1. PMID 21466787
    4. Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism. Bardowell SA, et al. J Lipid Res, 2012 Dec. PMID 22969154, Free PMC Article
    5. Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice. Ponnoth DS, et al. Am J Physiol Regul Integr Comp Physiol, 2012 Feb 15. PMID 22160543, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tHE TOH-omega-hydroxylase activity was exhibited by microsomes from mouse and human small intestine; murine activity was entirely due to CYP4F14.
      Title: Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.
    2. CYP4F14 is the major but not the only vitamin E-omega-hydroxylase in mice
      Title: Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.
    3. The data suggested that, in the absence of A2A adenosine receptor, omega-hydroxylase induces vasoconstriction through mitogen-activated protein kinases via upregulation of adenosine A1 receptor and protein kinase C-alpha.
      Title: Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.
    4. Catalytic activity of Cyp4fs is a novel target for modulating neuroinflammation through hydroxylation of LTB(4).
      Title: Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-tocopherol omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene B4 catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene B4 catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene B4 catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in omega-hydroxylase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leukotriene-B4 omega-hydroxylase 3
    Names
    cytochrome P450 4F14
    cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)
    cytochrome P450-LTB-omega
    leukotriene-B4 20-monooxygenase 3
    NP_001191262.1
    NP_001191263.1
    NP_001191264.1
    NP_001191265.1
    NP_001344717.1
    NP_071879.1
    XP_030105833.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204333.1 → NP_001191262.1  leukotriene-B4 omega-hydroxylase 3

      See identical proteins and their annotated locations for NP_001191262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AB037540, AK018676, BY705215
      Consensus CDS
      CCDS28621.1
      UniProtKB/Swiss-Prot
      Q52L93, Q9EP75
      Related
      ENSMUSP00000157036.2, ENSMUST00000234759.2
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 511
      p450; Cytochrome P450

    2. NM_001204334.1 → NP_001191263.1  leukotriene-B4 omega-hydroxylase 3

      See identical proteins and their annotated locations for NP_001191263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AB037540, AB037541, BY705215
      Consensus CDS
      CCDS28621.1
      UniProtKB/Swiss-Prot
      Q52L93, Q9EP75
      Related
      ENSMUSP00000157006.2, ENSMUST00000235058.2
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 511
      p450; Cytochrome P450

    3. NM_001204335.1 → NP_001191264.1  leukotriene-B4 omega-hydroxylase 3

      See identical proteins and their annotated locations for NP_001191264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AB037540, AI047403, CX200266
      Consensus CDS
      CCDS28621.1
      UniProtKB/Swiss-Prot
      Q52L93, Q9EP75
      Related
      ENSMUSP00000136139.2, ENSMUST00000179434.8
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 511
      p450; Cytochrome P450

    4. NM_001204336.1 → NP_001191265.1  leukotriene-B4 omega-hydroxylase 3

      See identical proteins and their annotated locations for NP_001191265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      CT033772
      Consensus CDS
      CCDS28621.1
      UniProtKB/Swiss-Prot
      Q52L93, Q9EP75
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 511
      p450; Cytochrome P450

    5. NM_001357788.1 → NP_001344717.1  leukotriene-B4 omega-hydroxylase 3

      Status: VALIDATED

      Source sequence(s)
      AB037540, CT033772
      Consensus CDS
      CCDS28621.1
      UniProtKB/Swiss-Prot
      Q52L93, Q9EP75
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 511
      p450; Cytochrome P450

    6. NM_022434.2 → NP_071879.1  leukotriene-B4 omega-hydroxylase 3

      See identical proteins and their annotated locations for NP_071879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AB037540, CT033772
      Consensus CDS
      CCDS28621.1
      UniProtKB/Swiss-Prot
      Q52L93, Q9EP75
      Related
      ENSMUSP00000050478.7, ENSMUST00000054174.9
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 511
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33122331..33136353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249973.2 → XP_030105833.1  leukotriene-B4 omega-hydroxylase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q52L93, Q9EP75
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 511
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EP75.1 GenPept UniProtKB/Swiss-Prot:Q9EP75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous