usp-50 ubiquitinyl hydrolase 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: usp-50
Official Full Name: ubiquitinyl hydrolase 1
Primary source: WormBase:WBGene00008441
Locus tag: CELE_E01B7.1
See related: AllianceGenome:WB:WBGene00008441
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in ERAD pathway and regulation of protein stability. Predicted to be located in early endosome. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_507513.2

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