U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cogc-4 Conserved oligomeric Golgi complex subunit 4 [ Caenorhabditis elegans ]

    Gene ID: 173518, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cogc-4
    Official Full Name
    Conserved oligomeric Golgi complex subunit 4
    Primary source
    WormBase:WBGene00021784
    Locus tag
    CELE_Y51H7C.6
    See related
    AllianceGenome:WB:WBGene00021784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cogc-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (1403441..1409118)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Nuclear nucleic acid-binding protein C1D Neighboring gene Immediate early response 3-interacting protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-serine deaminase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Saul-Wilson Syndrome Missense Allele Does Not Show Obvious Golgi Defects in a C. elegans Model. Zafra I, et al. MicroPubl Biol, 2021 Mar 4. PMID 33688625, Free PMC Article
    2. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Kubota Y, et al. Development, 2006 Jan. PMID 16354716
    3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Conserved oligomeric Golgi complex subunit 4
    NP_001033341.1
    • Confirmed by transcript evidence
    NP_493966.1
    • Confirmed by transcript evidence
    NP_493967.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1403441..1409118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061565.7 → NP_493966.1  Conserved oligomeric Golgi complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493966.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3V5K1, Q95XY9, Q95XZ0
      Conserved Domains (2) summary
      smart00762
      Location:198 → 527
      Cog4; COG4 transport protein
      pfam04437
      Location:562 → 789
      RINT1_TIP1; RINT-1 / TIP-1 family

    2. NM_001038252.4 → NP_001033341.1  Conserved oligomeric Golgi complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XZ0
      Conserved Domains (1) summary
      cl07072
      Location:198 → 257
      COG4; COG4 transport protein

    3. NM_061566.7 → NP_493967.1  Conserved oligomeric Golgi complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XZ0
      Conserved Domains (1) summary
      smart00762
      Location:198 → 471
      Cog4; COG4 transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XZ0.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.