U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    apb-1 AP complex subunit beta [ Caenorhabditis elegans ]

    Gene ID: 175376, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    apb-1
    Official Full Name
    AP complex subunit beta
    Primary source
    WormBase:WBGene00000160
    Locus tag
    CELE_Y71H2B.10
    See related
    AllianceGenome:WB:WBGene00000160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin binding activity. Involved in embryo development and receptor-mediated endocytosis. Predicted to be located in cytoplasm and membrane. Predicted to be part of clathrin adaptor complex. Is expressed in nervous system and pharynx. Orthologous to several human genes including AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See apb-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (2583971..2597034, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol transfer protein Neighboring gene FTH domain-containing protein Neighboring gene G Protein, Alpha subunit Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 19 Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. Shim J, et al. Mol Biol Cell, 2000 Aug. PMID 10930467, Free PMC Article
    2. Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans. Gu M, et al. J Cell Biol, 2008 Dec 1. PMID 19047463, Free PMC Article
    3. Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Kang YL, et al. Mol Biol Cell, 2013 Feb. PMID 23242996, Free PMC Article
    4. Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans. Kamikura DM, et al. Traffic, 2006 Mar. PMID 16497226
    5. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. Chen D, et al. PLoS Genet, 2013 May. PMID 23696751, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    AP complex subunit beta
    NP_001022937.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2583971..2597034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027766.5 → NP_001022937.1  AP complex subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022937.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4F3
      Conserved Domains (5) summary
      smart00809
      Location:736 → 834
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:844 → 955
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:11 → 531
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:99 → 265
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous