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    aex-3 MAP kinase-activating death domain protein [ Caenorhabditis elegans ]

    Gene ID: 180420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aex-3
    Official Full Name
    MAP kinase-activating death domain protein
    Primary source
    WormBase:WBGene00000086
    Locus tag
    CELE_C02H7.3
    See related
    AllianceGenome:WB:WBGene00000086
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of digestive system process. Predicted to be located in cytoplasm; plasma membrane; and synapse. Predicted to be active in cytosol. Is expressed in intestine and neurons. Used to study alcohol use disorder. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aex-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    21
    Sequence:
    Chromosome: X; NC_003284.9 (751203..759734, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TRAF3-interacting protein 1 Neighboring gene Translocon-associated protein subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemosensory cell function in the behavior and development of Caenorhabditis elegans. Bargmann CI, et al. Cold Spring Harb Symp Quant Biol, 1990. PMID 2132836
    2. Neuronal ERK signaling in response to graphene oxide in nematode Caenorhabditis elegans. Qu M, et al. Nanotoxicology, 2017 May. PMID 28368775
    3. Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans. Rytinki MM, et al. Cell Mol Life Sci, 2011 Oct. PMID 21253676, Free PMC Article
    4. Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Kapfhamer D, et al. Genes Brain Behav, 2008 Aug. PMID 18397381, Free PMC Article
    5. Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. Nonet ML, et al. J Neurosci, 1997 Nov 1. PMID 9334382, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data suggest that AEX-3 activates RAB-3 in the context of AVG axon navigation.
      Title: Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport involved in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of anterior/posterior axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of anterior/posterior axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intestinal lipid absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ventral cord development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-activating death domain protein
    NP_001024342.1
    • Confirmed by transcript evidence
    NP_741710.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      751203..759734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171618.6 → NP_741710.1  MAP kinase-activating death domain protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02626, Q27467, Q8MQF4
      Conserved Domains (3) summary
      smart00801
      Location:420 → 489
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:144 → 364
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 112
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. NM_001029171.7 → NP_001024342.1  MAP kinase-activating death domain protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02626
      Conserved Domains (3) summary
      smart00801
      Location:420 → 489
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:144 → 364
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 112
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02626.1

    Gene LinkOut

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