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    tam-1 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tam-1
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00006523
    Locus tag
    CELE_F26G5.9
    See related
    AllianceGenome:WB:WBGene00006523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in chromosome segregation; negative regulation of vulval development; and transcription initiation-coupled chromatin remodeling. Located in germ cell nucleus. Is expressed in several structures, including germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tam-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (4958603..4963102, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Seven TM Receptor Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16. Procko C, et al. Genetics, 2012 Apr. PMID 22298710, Free PMC Article
    2. New genetic regulators question relevance of abundant yolk protein production in C. elegans. Van Rompay L, et al. Sci Rep, 2015 Nov 10. PMID 26553710, Free PMC Article
    3. The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans. Tseng RJ, et al. Mol Genet Genomics, 2007 Nov. PMID 17618463
    4. Recognition and silencing of repeated DNA. Hsieh J, et al. Annu Rev Genet, 2000. PMID 11092826
    5. CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Ma DK, et al. Neuron, 2012 Mar 8. PMID 22405203, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_504335.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4958603..4963102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071934.7 → NP_504335.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED20
      Conserved Domains (3) summary
      pfam11498
      Location:339 → 524
      Activator_LAG-3; Transcriptional activator LAG-3
      PTZ00341
      Location:691 → 805
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cl17238
      Location:21 → 48
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

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