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    F47D12.9 WD_REPEATS_REGION domain-containing protein;putative WD repeat-containing protein F47D12.9 [ Caenorhabditis elegans ]

    Gene ID: 175892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F47D12.9
    Official Full Name
    WD_REPEATS_REGION domain-containing protein;putative WD repeat-containing protein F47D12.9
    Primary source
    WormBase:WBGene00018564
    Locus tag
    CELE_F47D12.9
    See related
    AllianceGenome:WB:WBGene00018564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF4 (DDB1 and CUL4 associated factor 4); DCAF4L1 (DDB1 and CUL4 associated factor 4 like 1); and DCAF4L2 (DDB1 and CUL4 associated factor 4 like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F47D12.9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (6299332..6302507, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Kelch repeat and BTB domain-containing protein F47D12.7 Neighboring gene Uncharacterized protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2 Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD_REPEATS_REGION domain-containing protein;putative WD repeat-containing protein F47D12.9
    NP_001370865.1
    • Confirmed by transcript evidence
    NP_498382.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6299332..6302507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065981.7 → NP_498382.2  putative WD repeat-containing protein F47D12.9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498382.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09392
      Conserved Domains (3) summary
      COG2319
      Location:369 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:465 → 504
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:432 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001382890.2 → NP_001370865.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7J9
      Conserved Domains (2) summary
      COG2319
      Location:236 → 378
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:332 → 371
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09392.1

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