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    imp-1 IntraMembrane Protease (IMPAS) family [ Caenorhabditis elegans ]

    Gene ID: 172684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    imp-1
    Official Full Name
    IntraMembrane Protease (IMPAS) family
    Primary source
    WormBase:WBGene00007979
    Locus tag
    CELE_C36B1.12
    See related
    AllianceGenome:WB:WBGene00007979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Predicted to be involved in membrane protein proteolysis. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SPPL2A (signal peptide peptidase like 2A); SPPL2B (signal peptide peptidase like 2B); and SPPL2C (signal peptide peptidase like 2C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See imp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (8752229..8755680)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene SWEET sugar transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease. Grigorenko AP, et al. Oncotarget, 2017 Oct 10. PMID 29137240, Free PMC Article
    2. Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs. Henricson A, et al. BMC Genomics, 2004 Nov 8. PMID 15533247, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    IntraMembrane Protease (IMPAS) family
    NP_001021023.1
    • Product from WormBase gene class imp;
      Confirmed by transcript evidence
    NP_001021024.1
    • Product from WormBase gene class imp;
      Confirmed by transcript evidence
    NP_001021025.1
    • Product from WormBase gene class imp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8752229..8755680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025854.6 → NP_001021025.1  IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021025.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q564X0
      Conserved Domains (1) summary
      pfam04258
      Location:275 → 601
      Peptidase_A22B; Signal peptide peptidase

    2. NM_001025852.5 → NP_001021023.1  IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93346
      Conserved Domains (1) summary
      pfam04258
      Location:275 → 601
      Peptidase_A22B; Signal peptide peptidase

    3. NM_001025853.6 → NP_001021024.1  IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q564X1
      Conserved Domains (1) summary
      pfam04258
      Location:275 → 601
      Peptidase_A22B; Signal peptide peptidase
    Nucleotide Protein
    Heading Accession and Version

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