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    • Showing Current items.

    iglr-2 Immunoglobulin domain and leucine-rich repeat-containing protein 2 [ Caenorhabditis elegans ]

    Gene ID: 176175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    iglr-2
    Official Full Name
    Immunoglobulin domain and leucine-rich repeat-containing protein 2
    Primary source
    WormBase:WBGene00022580
    Locus tag
    CELE_ZC262.3
    See related
    AllianceGenome:WB:WBGene00022580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Is expressed in gonadal sheath cell; intestine; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See iglr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (8326582..8330947, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene EB domain-containing protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene 28S ribosomal protein S18a, mitochondrial Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Cytochrome C biogenesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated fats. Devkota R, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Apr. PMID 33444761
    2. Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2. Bodhicharla R, et al. Genetics, 2018 Sep. PMID 29997234, Free PMC Article
    3. Regulation and functions of membrane lipids: Insights from Caenorhabditis elegans. Koyiloth M, et al. BBA Adv, 2022. PMID 37082601, Free PMC Article
    4. A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone. Lee CH, et al. Sci Adv, 2023 Jan 18. PMID 36652525, Free PMC Article
    5. Leveraging the withered tail tip phenotype in C. elegans to identify proteins that influence membrane properties. Svensk E, et al. Worm, 2016. PMID 27695656, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated fats.
      Title: The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated fats.
    2. IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans.
      Title: IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans.
    3. Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
      Title: Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
    4. PAQR-2 and IGLR-2 interact on plasma membranes and thus may act together as a fluidity sensor that controls membrane lipid composition.
      Title: Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Immunoglobulin domain and leucine-rich repeat-containing protein 2
    NP_498834.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8326582..8330947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066433.9 → NP_498834.1  Immunoglobulin domain and leucine-rich repeat-containing protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34595
      Conserved Domains (6) summary
      cd00096
      Location:394 → 472
      Ig; Immunoglobulin domain
      cd00116
      Location:120 → 223
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:76 → 99
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01442
      Location:550 → 687
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam12799
      Location:168 → 206
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:168 → 219
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34595.2

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