erfa-3 Eukaryotic peptide chain release factor GTP-binding subunit;Translation elongation factor EFTu/EF1A C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: erfa-3
Official Full Name: Eukaryotic peptide chain release factor GTP-binding subunit;Translation elongation factor EFTu/EF1A C-terminal domain-containing protein
Primary source: WormBase:WBGene00010405
Locus tag: CELE_H19N07.1
See related: AllianceGenome:WB:WBGene00010405
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in translation. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in several structures, including anal depressor muscle; excretory cell; nervous system; rectal epithelium; and reproductive system. Orthologous to human GSPT1 (G1 to S phase transition 1) and GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See erfa-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (11110100..11113091, complement)

Chromosome V - NC_003283.11 $Genomic Context describing neighboring genes$

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H19N07.1 (e-PCR)
- UniSTS:311333

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation release factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info
involved_in translational termination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of translation release factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic peptide chain release factor GTP-binding subunit;Translation elongation factor EFTu/EF1A C-terminal domain-containing protein

NP_001256292.1

Confirmed by transcript evidence

NP_001367276.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11110100..11113091 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269363.4 → NP_001256292.1 Eukaryotic peptide chain release factor GTP-binding subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256292.1

Status: REVIEWED

UniProtKB/TrEMBL

O45622

Conserved Domains (2) summary

COG5256
Location:105 → 532

TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

pfam06121
Location:24 → 94

DUF959; Domain of Unknown Function (DUF959)
NM_001380755.1 → NP_001367276.1 Translation elongation factor EFTu/EF1A C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

E9P8A2

Conserved Domains (1) summary

cl02786
Location:1 → 40

Translation_factor_III; Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins