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    mfn-1 Mitoferrin [ Caenorhabditis elegans ]

    Gene ID: 174752, updated on 2-Nov-2024

    Summary

    Official Symbol
    mfn-1
    Official Full Name
    Mitoferrin
    Primary source
    WormBase:WBGene00012204
    Locus tag
    CELE_W02B12.9
    See related
    AllianceGenome:WB:WBGene00012204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial membrane. Is expressed in intestine and nervous system. Orthologous to several human genes including SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See mfn-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (11470003..11472016, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene Kinesin motor domain-containing protein Neighboring gene CDGSH iron-sulfur domain-containing protein 2 homologue;Iron-binding zinc finger CDGSH type domain-containing protein Neighboring gene tRNA (guanine-N(7)-)-methyltransferase Neighboring gene Beta-1,4-N-acetylgalactosaminyltransferase Neighboring gene Uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in iron import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Mitoferrin
    NP_001382726.1
    • Partially confirmed by transcript evidence
    NP_001391079.1
    • Partially confirmed by transcript evidence
    NP_001391080.1
    • Partially confirmed by transcript evidence
    NP_496447.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11470003..11472016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064046.7NP_496447.1  Mitoferrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23125
      Conserved Domains (1) summary
      pfam00153
      Location:14108
      Mito_carr; Mitochondrial carrier protein
    2. NM_001404239.1NP_001391079.1  Mitoferrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I609
    3. NM_001404240.1NP_001391080.1  Mitoferrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I610
    4. NM_001395808.1NP_001382726.1  Mitoferrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I8L7
      Conserved Domains (1) summary
      PTZ00168
      Location:22193
      PTZ00168; mitochondrial carrier protein; Provisional