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    epc-1 Enhancer of polycomb-like protein [ Caenorhabditis elegans ]

    Gene ID: 176679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epc-1
    Official Full Name
    Enhancer of polycomb-like protein
    Primary source
    WormBase:WBGene00007030
    Locus tag
    CELE_Y111B2A.11
    See related
    AllianceGenome:WB:WBGene00007030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of piccolo histone acetyltransferase complex. Is expressed in several structures, including body wall musculature; intestine; pharynx; tail; and vulval muscle. Orthologous to several human genes including EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See epc-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (12599630..12608467, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene CBS domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A chromodomain protein mediates heterochromatin-directed piRNA expression. Huang X, et al. Proc Natl Acad Sci U S A, 2021 Jul 6. PMID 34187893, Free PMC Article
    2. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Ceol CJ, et al. Dev Cell, 2004 Apr. PMID 15068795
    3. The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Rocheleau CE, et al. Genetics, 2008 Mar. PMID 18245826, Free PMC Article
    4. The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. Grote P, et al. Dev Cell, 2006 Oct. PMID 17011494
    5. Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans. Poulin G, et al. EMBO J, 2005 Jul 20. PMID 15990876, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of piccolo histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Enhancer of polycomb-like protein
    NP_001370109.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12599630..12608467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383013.2 → NP_001370109.1  Enhancer of polycomb-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC14
      Conserved Domains (1) summary
      pfam10513
      Location:9 → 131
      EPL1; Enhancer of polycomb-like
    Nucleotide Protein
    Heading Accession and Version

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