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    • Showing Current items.

    cox-5A Cytochrome c oxidase subunit 5A, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cox-5A
    Official Full Name
    Cytochrome c oxidase subunit 5A, mitochondrial
    Primary source
    WormBase:WBGene00012553
    Locus tag
    CELE_Y37D8A.14
    See related
    AllianceGenome:WB:WBGene00012553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cox-5A in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (12905491..12906619)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ENhancer of Uncoordination Neighboring gene Disintegrin and metalloproteinase domain-containing protein unc-71 Neighboring gene Uncharacterized protein Neighboring gene KHEYLRF-amide 4 Neighboring gene MARVEL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complex I function is defective in complex IV-deficient Caenorhabditis elegans. Suthammarak W, et al. J Biol Chem, 2009 Mar 6. PMID 19074434, Free PMC Article
    2. Genes that may modulate longevity in C. elegans in both dauer larvae and long-lived daf-2 adults. Ruzanov P, et al. Exp Gerontol, 2007 Aug. PMID 17543485, Free PMC Article
    3. Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Zuryn S, et al. Toxicol Sci, 2008 Mar. PMID 17998274
    4. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
    5. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome c oxidase subunit 5A, mitochondrial
    NP_499681.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12905491..12906619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067280.8 → NP_499681.1  Cytochrome c oxidase subunit 5A, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55954, Q9XWV8
      Conserved Domains (1) summary
      cd00923
      Location:37 → 142
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55954.2

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