unc-101 AP-1 complex subunit mu-1-I;MHD domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: unc-101
Official Full Name: AP-1 complex subunit mu-1-I;MHD domain-containing protein
Primary source: WormBase:WBGene00006829
Locus tag: CELE_K11D2.3
See related: AllianceGenome:WB:WBGene00006829
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin adaptor activity. Involved in several processes, including apical protein localization; nematode larval development; and receptor localization to non-motile cilium. Predicted to be located in Golgi apparatus; clathrin-coated vesicle membrane; and dendrite. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including germ line; head; nervous system; and tail. Orthologous to several human genes including AP1M1 (adaptor related protein complex 1 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See unc-101 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (12508299..12513420)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest UNC-101/AP-1 mu1 subunit exhibits a novel bipartite sorting signal within KVS-4/Kv2.1 consisting of C-terminal EQMIL and N-terminal WNIIE motifs; such sorting signals appear to account for somatodendritic distribution of KVS-4/Kv2.1.
Title: A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.
An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 basolateral localization and signaling during C. elegans vulva induction.
Title: An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

K11D2.3 (e-PCR)
- UniSTS:319513

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in apical protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vulval development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of AP-1 adaptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: AP-1 complex subunit mu-1-I;MHD domain-containing protein

NP_001040675.1

Confirmed by transcript evidence

NP_001040676.1

Partially confirmed by transcript evidence

NP_001251914.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12508299..12513420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047210.4 → NP_001040675.1 AP-1 complex subunit mu-1-I [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040675.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02282, P35602, Q1ZXR6

Conserved Domains (2) summary

cl02092
Location:5 → 126

Clat_adaptor_s; Clathrin adaptor complex small chain

cd09258
Location:152 → 421

AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
NM_001264985.3 → NP_001251914.1 MHD domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251914.1

Status: REVIEWED

UniProtKB/TrEMBL

D7SFR1

Conserved Domains (1) summary

cd09258
Location:3 → 272

AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
NM_001047211.3 → NP_001040676.1 AP-1 complex subunit mu-1-I [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040676.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35602

Conserved Domains (1) summary

cl10970
Location:1 → 57

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)