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    lec-11 Galectin [ Caenorhabditis elegans ]

    Gene ID: 177420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lec-11
    Official Full Name
    Galectin
    Primary source
    WormBase:WBGene00002274
    Locus tag
    CELE_F38A5.3
    See related
    AllianceGenome:WB:WBGene00002274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbohydrate binding activity and galactoside binding activity. Involved in innate immune response. Located in cytoplasm. Is expressed in intestine and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lec-11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (6588184..6590154, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ufm1-specific protease Neighboring gene TraB domain-containing protein Neighboring gene DnaJ homolog subfamily C member 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Receptor L-domain domain-containing protein Neighboring gene Nematode Specific Peptide family, group B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB. Goswamy D, et al. Front Immunol, 2023. PMID 36860863, Free PMC Article
    2. The DC2.3 gene in Caenorhabditis elegans encodes a galectin that recognizes the galactoseβ1→4fucose disaccharide unit. Nemoto-Sasaki Y, et al. Biol Pharm Bull, 2011. PMID 21963509
    3. Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine. Maduzia LL, et al. J Biol Chem, 2011 Feb 11. PMID 21115491, Free PMC Article
    4. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319
    5. Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. Nandakumar M, et al. PLoS Genet, 2008 Nov. PMID 19023415, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Galectin
    NP_001023191.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6588184..6590154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028020.6 → NP_001023191.1  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94215, Q9GNP8
      Conserved Domains (1) summary
      pfam00337
      Location:11 → 140
      Gal-bind_lectin; Galactoside-binding lectin

    RNA

    1. NR_131549.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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