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    lin-44 Abnormal cell lineage protein 44 [ Caenorhabditis elegans ]

    Gene ID: 171994, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-44
    Official Full Name
    Abnormal cell lineage protein 44
    Primary source
    WormBase:WBGene00003029
    Locus tag
    CELE_E01A2.3
    See related
    AllianceGenome:WB:WBGene00003029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including nematode male tail tip morphogenesis; neuron migration; and positive regulation of cell projection organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including P6.pa; anchor cell; hypodermis; rectal epithelial cell; and tail. Human ortholog(s) of this gene implicated in ectodermal dysplasia (multiple); obesity; oral squamous cell carcinoma; split hand-foot malformation 6; and tooth agenesis. Orthologous to several human genes including WNT10A (Wnt family member 10A); WNT10B (Wnt family member 10B); and WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-44 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (4126056..4129310)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Basic proline-rich protein Neighboring gene NF-kappa-B-activating protein C-terminal domain-containing protein Neighboring gene Serrate RNA effector molecule homolog Neighboring gene Diphthine--ammonia ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Sawa H, et al. Genes Dev, 1996 Sep 1. PMID 8804313
    2. C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons. Huarcaya Najarro E, et al. Dev Biol, 2013 May 1. PMID 23376536, Free PMC Article
    3. Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans. Lu M, et al. Elife, 2019 Dec 5. PMID 31804181, Free PMC Article
    4. Mutations in the Caenorhabditis elegans gene vab-3 reveal distinct roles in fate specification and unequal cytokinesis in an asymmetric cell division. Chamberlin HM, et al. Dev Biol, 1995 Aug. PMID 7649393
    5. TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals and controls male tail tip morphogenesis in C. elegans. Zhao X, et al. Development, 2002 Mar. PMID 11880358

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIN-17 and DSH-1/Dishevelled proteins were recruited to the pruning neurites in lin-44-dependent manners.
      Title: Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans.
    2. The Wnt ligand lin-44 contributes to the early stages of gastrulation in parallel to sdn-1, but in a genetic pathway with ptp-3.
      Title: A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis.
    3. In sensory neurons, the posteriorly enriched LIN-44/Wnt acts as a repellent to promote anteriorly directed neurite outgrowth through the LIN-17/Frizzled receptor, instead of controlling neuronal polarity as previously thought.
      Title: Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans.
    4. our results strongly suggest that functions of at least four Wnts (lin-44, cwn-1, cwn-2, and egl-20) determine the polarity orientation of seam cells
      Title: Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
    5. LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons.
      Title: LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables receptor ligand activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate specification involved in pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in generation of neurons IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interneuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Abnormal cell lineage protein 44
    NP_001021081.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4126056..4129310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025910.5 → NP_001021081.1  Abnormal cell lineage protein 44 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27886, Q6F3D0
      Conserved Domains (1) summary
      smart00097
      Location:64 → 339
      WNT1; found in Wnt-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27886.1

    Gene LinkOut

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