ulp-1 Sentrin-specific protease [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ulp-1
Official Full Name: Sentrin-specific protease
Primary source: WormBase:WBGene00006736
Locus tag: CELE_T10F2.3
See related: AllianceGenome:WB:WBGene00006736
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable deSUMOylase activity. Involved in several processes, including embryo development; positive regulation of error-prone translesion synthesis; and protein desumoylation. Predicted to be located in nuclear envelope. Predicted to be active in nucleus. Orthologous to several human genes including SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ulp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (5165659..5169799, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study using C. elegans as a model system found that SUMO promotes the stability of the ring complex (RC) and that RC disassembly is dependent on targeting the SUMO protease ULP-1 to the structures, suggesting that ULP-1 could promote RC disassembly upon removal of the E2/E3 enzymes in early anaphase.
Title: Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T10F2.4 (e-PCR)
- UniSTS:310791

T10F2.3 (e-PCR)
- UniSTS:314961

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of error-prone translesion synthesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of error-prone translesion synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Sentrin-specific protease

NP_498095.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5165659..5169799 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065694.9 → NP_498095.3 Sentrin-specific protease [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498095.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09353, Q8IU18

Conserved Domains (1) summary

cl23802
Location:425 → 692

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain