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    hut-1 UAA transporter [ Caenorhabditis elegans ]

    Gene ID: 176690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hut-1
    Official Full Name
    UAA transporter
    Primary source
    WormBase:WBGene00013740
    Locus tag
    CELE_Y111B2A.20
    See related
    AllianceGenome:WB:WBGene00013740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable UDP-galactose transmembrane transporter activity and UDP-glucose transmembrane transporter activity. Involved in endoplasmic reticulum organization and nematode larval development. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in coelomocyte; egg-laying apparatus; gonad; intestine; and pharyngeal cell. Orthologous to human SLC35B1 (solute carrier family 35 member B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hut-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (12711560..12713874)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene C2 domain-containing protein Neighboring gene Helicase ssl-1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. Dejima K, et al. FASEB J, 2009 Jul. PMID 19270184, Free PMC Article
    2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate important roles for hut-1 (Y111B2A.20)in development and maintenance of endoplasmic reticulum homeostasis in C. elegans
      Title: The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in UDP-galactose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UAA transporter
    NP_001293604.1
    • Confirmed by transcript evidence
    NP_499652.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12711560..12713874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067251.5 → NP_499652.1  UAA transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BHL2
      Conserved Domains (2) summary
      pfam08449
      Location:24 → 314
      UAA; UAA transporter family
      cl23754
      Location:177 → 314
      EamA; EamA-like transporter family

    2. NM_001306675.1 → NP_001293604.1  UAA transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLL6
    Nucleotide Protein
    Heading Accession and Version

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