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    ech-7 Enoyl-CoA hydratase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 173300, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ech-7
    Official Full Name
    Enoyl-CoA hydratase, mitochondrial
    Primary source
    WormBase:WBGene00001156
    Locus tag
    CELE_Y105E8A.4
    See related
    AllianceGenome:WB:WBGene00001156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial short-chain enoyl-CoA hydratase 1 deficiency. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ech-7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (14367616..14369773, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum lectin 1 Neighboring gene Proton-coupled zinc antiporter SLC30A5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BBSome complex member BBS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. Svensk E, et al. PLoS Genet, 2013. PMID 24068966, Free PMC Article
    2. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Heimbucher T, et al. Nat Commun, 2020 Oct 2. PMID 33009389, Free PMC Article
    3. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Enoyl-CoA hydratase, mitochondrial
    NP_740932.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14367616..14369773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170936.5 → NP_740932.1  Enoyl-CoA hydratase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NEZ8
      Conserved Domains (2) summary
      PRK05617
      Location:13 → 253
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      cl23717
      Location:12 → 254
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    Nucleotide Protein
    Heading Accession and Version

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