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    csa-1 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csa-1
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00008403
    Locus tag
    CELE_D2013.3
    See related
    AllianceGenome:WB:WBGene00008403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and transcription-coupled nucleotide-excision repair. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See csa-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (9317551..9319726, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Acyl-CoA synthetase 7 Neighboring gene Golgi apparatus protein 1 Neighboring gene Tyrosine-protein kinase receptor cam-1 Neighboring gene ncRNA Neighboring gene WD repeat and FYVE domain-containing protein 2 Neighboring gene ncRNA Neighboring gene Ras-related protein rab-39

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A C. elegans homolog of the Cockayne syndrome complementation group A gene. Babu V, et al. DNA Repair (Amst), 2014 Dec. PMID 25453470, Free PMC Article
    2. MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. Bianco JN, et al. Nucleic Acids Res, 2018 Jul 6. PMID 29788264, Free PMC Article
    3. A C. elegans model for neurodegeneration in Cockayne syndrome. Lopes AFC, et al. Nucleic Acids Res, 2020 Nov 4. PMID 33021672, Free PMC Article
    4. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Wilson DM 3rd, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934497, Free PMC Article
    5. The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Bujarrabal-Dueso A, et al. Nat Struct Mol Biol, 2023 Apr. PMID 36959262, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-excision repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_495982.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9317551..9319726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063581.5 → NP_495982.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18963
      Conserved Domains (3) summary
      COG2319
      Location:49 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:53 → 95
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:44 → 264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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