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    fndc-1 FUN14 domain-containing protein fndc-1 [ Caenorhabditis elegans ]

    Gene ID: 174714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fndc-1
    Official Full Name
    FUN14 domain-containing protein fndc-1
    Primary source
    WormBase:WBGene00011528
    Locus tag
    CELE_T06D8.7
    See related
    AllianceGenome:WB:WBGene00011528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in mitophagy. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC1 (FUN14 domain containing 1) and FUNDC2 (FUN14 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fndc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (11236624..11237325, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UVR domain-containing protein Neighboring gene EOG090X04TT Neighboring gene putative holocytochrome-c-type synthase Neighboring gene ncRNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 13 Neighboring gene Store-operated calcium entry-associated regulatory factor Neighboring gene Peroxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fndc-1 contributes to paternal mitochondria elimination in C. elegans. Lim Y, et al. Dev Biol, 2019 Oct 1. PMID 31233739, Free PMC Article
    2. FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation. Lim Y, et al. Autophagy, 2021 Nov. PMID 33416042, Free PMC Article
    3. Ubiquitination is required for the initial removal of paternal organelles in C. elegans. Molina P, et al. Dev Biol, 2019 Sep 15. PMID 31153831, Free PMC Article
    4. A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target. Andachi Y. RNA, 2008 Nov. PMID 18824511, Free PMC Article
    5. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
      Title: FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FUN14 domain-containing protein fndc-1
    NP_496404.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11236624..11237325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064003.7 → NP_496404.1  FUN14 domain-containing protein fndc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22252
      Conserved Domains (1) summary
      pfam04930
      Location:41 → 135
      FUN14; FUN14 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22252.1

    Gene LinkOut

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