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    D1037.1 Protein SON [ Caenorhabditis elegans ]

    Gene ID: 171936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    D1037.1
    Official Full Name
    Protein SON
    Primary source
    WormBase:WBGene00017025
    Locus tag
    CELE_D1037.1
    See related
    AllianceGenome:WB:WBGene00017025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Human ortholog(s) of this gene implicated in ZTTK syndrome and congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay. Orthologous to human SON (SON DNA and RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See D1037.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (3684781..3690347)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ferritin Neighboring gene Ras-related protein Rab-8A Neighboring gene phospholipase A2 Neighboring gene DNA mismatch repair proteins mutS family domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein SON
    NP_491200.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3684781..3690347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058799.6 → NP_491200.1  Protein SON [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TYS1
      Conserved Domains (2) summary
      cd00048
      Location:706 → 773
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam01585
      Location:637 → 681
      G-patch; G-patch domain
    Nucleotide Protein
    Heading Accession and Version

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