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    bris-1 SEC7 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177142, updated on 2-Nov-2024

    Summary

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    Official Symbol
    bris-1
    Official Full Name
    SEC7 domain-containing protein
    Primary source
    WormBase:WBGene00019726
    Locus tag
    CELE_M02B7.5
    See related
    AllianceGenome:WB:WBGene00019726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Is expressed in hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities; lung adenocarcinoma; and non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1); IQSEC2 (IQ motif and Sec7 domain ArfGEF 2); and IQSEC3 (IQ motif and Sec7 domain ArfGEF 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See bris-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (3807870..3819328, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FTH domain-containing protein Neighboring gene ncRNA Neighboring gene DUF1014-domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity. Chen D, et al. J Cell Biol, 2018 Jun 4. PMID 29563216, Free PMC Article
    2. Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans. Teuliere J, et al. Genetics, 2014 Sep. PMID 25053664, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SEC7 domain-containing protein
    NP_001294288.1
    • Confirmed by transcript evidence
    NP_001368213.1
    • Confirmed by transcript evidence
    NP_001368214.1
    • Confirmed by transcript evidence
    NP_500420.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3807870..3819328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068019.6 → NP_500420.3  SEC7 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500420.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94287
      Conserved Domains (2) summary
      cd13318
      Location:445 → 573
      PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
      pfam01369
      Location:224 → 417
      Sec7; Sec7 domain

    2. NM_001307359.4 → NP_001294288.1  SEC7 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PAR9
      Conserved Domains (2) summary
      cd13318
      Location:366 → 494
      PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
      pfam01369
      Location:145 → 338
      Sec7; Sec7 domain

    3. NM_001380166.1 → NP_001368213.1  SEC7 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB66
      Conserved Domains (2) summary
      cd00171
      Location:86 → 279
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      pfam16453
      Location:300 → 435
      IQ_SEC7_PH; PH domain

    4. NM_001380167.2 → NP_001368214.1  SEC7 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PLL0
      Conserved Domains (2) summary
      cd00171
      Location:81 → 274
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      pfam16453
      Location:295 → 430
      IQ_SEC7_PH; PH domain
    Nucleotide Protein
    Heading Accession and Version

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