eat-2 Neuronal acetylcholine receptor subunit eat-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eat-2
Official Full Name: Neuronal acetylcholine receptor subunit eat-2
Primary source: WormBase:WBGene00001133
Locus tag: CELE_Y48B6A.4
See related: AllianceGenome:WB:WBGene00001133
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including determination of adult lifespan; regulation of eating behavior; and regulation of gene expression. Located in neuromuscular junction and plasma membrane. Part of acetylcholine-gated channel complex. Is expressed in pm4 and pm5. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eat-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (14166878..14171658, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment.
Title: EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment.
Measuring Caenorhabditis elegans Spatial Foraging and Food Intake Using Bioluminescent Bacteria.
Title: Measuring Caenorhabditis elegans Spatial Foraging and Food Intake Using Bioluminescent Bacteria.
eat-2(lf) mutants displayed a similar phenotype, indicating accumulation of live bacteria also triggers extended longevity in this mutant. The analysis of phm-2 elucidates connections between pathogen response and aging by defining a mechanism of longevity extension in C. elegans-bacterial colonization, innate immune activation, and bacterial avoidance behavior.
Title: Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response.
Cross talk between the nAChR EAT-2 and the mAChR GAR-3 affects peristaltic muscle contractions in the isthmus of the C. elegans pharynx.
Title: Cross Talk with the GAR-3 Receptor Contributes to Feeding Defects in Caenorhabditis elegans eat-2 Mutants.
Eat-2 mutants, a model of Dietary Restriction (DR), exhibit impaired long-term memory in young adulthood but maintain this level of memory longer with age.
Title: Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.
Allele-specific genetic interactions between eat-2 and eat-18 suggest that EAT-18 interacts physically with the EAT-2 receptor.
Title: eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx.

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General gene information

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Markers

Y48B6A.4 (e-PCR)
- UniSTS:321740

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of brood size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neuronal acetylcholine receptor subunit eat-2

NP_496959.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14166878..14171658 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064558.6 → NP_496959.1 Neuronal acetylcholine receptor subunit eat-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496959.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U298

Conserved Domains (3) summary

TIGR00860
Location:3 → 459

LIC; Cation transporter family protein

pfam02931
Location:25 → 234

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:242 → 456

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region