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    camt-1 Calmodulin-binding transcription activator homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 173786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    camt-1
    Official Full Name
    Calmodulin-binding transcription activator homolog 1
    Primary source
    WormBase:WBGene00020251
    Locus tag
    CELE_T05C1.4
    See related
    AllianceGenome:WB:WBGene00020251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables chromatin binding activity. Involved in positive chemotaxis; positive regulation of transcription by RNA polymerase II; and response to oxygen levels. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in nonprogressive cerebellar ataxia with mental retardation. Orthologous to several human genes including CAMTA2 (calmodulin binding transcription activator 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See camt-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    19
    Sequence:
    Chromosome: II; NC_003280.10 (4491152..4505147, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene Myoblast determination protein 1 homolog Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal calmodulin levels are controlled by CAMTA transcription factors. Vuong-Brender TT, et al. Elife, 2021 Sep 9. PMID 34499028, Free PMC Article
    2. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
    3. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    4. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of macromolecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of primary metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calmodulin-binding transcription activator homolog 1
    NP_001022314.1
    • Confirmed by transcript evidence
    NP_494795.2
    • Partially confirmed by transcript evidence
    NP_494796.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4491152..4505147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062395.3 → NP_494796.2  Calmodulin-binding transcription activator homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494796.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KY85
      Conserved Domains (6) summary
      smart00015
      Location:982 → 1003
      IQ; Calmodulin-binding motif
      smart01076
      Location:76 → 195
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00102
      Location:415 → 499
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cd00204
      Location:577 → 654
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:580 → 658
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:616 → 648
      ANK; ANK repeat [structural motif]

    2. NM_062394.5 → NP_494795.2  Calmodulin-binding transcription activator homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494795.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KY84, H2KY85, Q629J3
      Conserved Domains (6) summary
      smart00015
      Location:982 → 1003
      IQ; Calmodulin-binding motif
      smart01076
      Location:76 → 195
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00102
      Location:415 → 499
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cd00204
      Location:577 → 654
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:580 → 658
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:616 → 648
      ANK; ANK repeat [structural motif]

    3. NM_001027143.6 → NP_001022314.1  Calmodulin-binding transcription activator homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q629J3
    Nucleotide Protein
    Heading Accession and Version

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