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    glrx-21 Glutaredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glrx-21
    Official Full Name
    Glutaredoxin domain-containing protein
    Primary source
    WormBase:WBGene00022663
    Locus tag
    CELE_ZK121.1
    See related
    AllianceGenome:WB:WBGene00022663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be active in mitochondrion. Is expressed in nervous system. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glrx-21 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (5345264..5346117, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Suppressor of organelle fusion 2 Neighboring gene R3H domain-containing protein Neighboring gene THO complex subunit 5 Neighboring gene pseudo Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Dehydrogenase/reductase SDR family member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans. Morgan KL, et al. Toxicol Sci, 2010 Dec. PMID 20833709, Free PMC Article
    2. Redox properties and evolution of human glutaredoxins. Sagemark J, et al. Proteins, 2007 Sep 1. PMID 17546662
    3. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLRX-21 is required for glutathione to moderate this selenium-induced lethality.
      Title: The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutaredoxin domain-containing protein
    NP_001040891.1
    • Confirmed by transcript evidence
    NP_001040892.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5345264..5346117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047426.4 → NP_001040891.1  Glutaredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4P2
      Conserved Domains (1) summary
      COG0695
      Location:21 → 104
      GrxC; Glutaredoxin [Posttranslational modification, protein turnover, chaperones]

    2. NM_001047427.4 → NP_001040892.1  Glutaredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2AAC3
      Conserved Domains (1) summary
      COG0695
      Location:1 → 81
      GrxC; Glutaredoxin [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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