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    eri-6 Enhanced RNAI (RNA interference) [ Caenorhabditis elegans ]

    Gene ID: 172050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eri-6
    Official Full Name
    Enhanced RNAI (RNA interference)
    Primary source
    WormBase:WBGene00016561
    Locus tag
    CELE_C41D11.1
    See related
    AllianceGenome:WB:WBGene00016561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in ASIL; ASIR; ASKL; ASKR; and hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eri-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (4457375..4469458)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein cmt-1 Neighboring gene Enhanced RNAI (RNA interference) Neighboring gene DNA2/NAM7 helicase helicase domain-containing protein Neighboring gene ncRNA Neighboring gene Small integral membrane protein 8 Neighboring gene ncRNA Neighboring gene Receptor-type guanylate cyclase gcy-28 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Fischer SEJ, et al. Proc Natl Acad Sci U S A, 2020 Mar 17. PMID 32123111, Free PMC Article
    2. A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans. Rogers AK, et al. Cell Rep, 2020 Oct 20. PMID 33086057, Free PMC Article
    3. Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants. Zhuang JJ, et al. Genetics, 2011 May. PMID 21385728, Free PMC Article
    4. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Fischer SE, et al. Nature, 2008 Sep 25. PMID 18784652, Free PMC Article
    5. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Fischer SE, et al. Genes Dev, 2013 Dec 15. PMID 24352423, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans.
      Title: A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans.
    2. eri-6 and eri-7 produce separate pre-messenger RNAs (pre-mRNAs) that are trans-spliced to form a functional mRNA, eri-6/7 [eri-6; eri-7]
      Title: Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    General protein information

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    Preferred Names
    Enhanced RNAI (RNA interference)
    NP_001249622.1
    • Product from WormBase gene class eri;
      Confirmed by transcript evidence
    NP_001249624.1
    • Product from WormBase gene class eri;
      Confirmed by transcript evidence
    NP_001249625.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class eri
    NP_001367500.1
    • Product from WormBase gene class eri;
      Confirmed by transcript evidence
    NP_001379661.1
    • Product from WormBase gene class eri;
      Confirmed by transcript evidence
    NP_001380040.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class eri

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4457375..4469458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001262695.4 → NP_001249624.1  Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5TRE2, G4RZ45

    2. NM_001262696.4 → NP_001249625.1  Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5TRE2, G4RZ49, G5EET9

    3. NM_001379821.1 → NP_001367500.1  Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5TRE2, G4RZ46

    4. NM_001262693.4 → NP_001249622.1  Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5TRE2, G4RZ48

    5. NM_001392152.1 → NP_001379661.1  Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SPR0, G5EDX2
      Conserved Domains (1) summary
      pfam06918
      Location:69 → 272
      DUF1280; Protein of unknown function (DUF1280)

    6. NM_001392154.1 → NP_001380040.1  Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4RZ35
    Nucleotide Protein
    Heading Accession and Version

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