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    osm-12 BBSome complex member bbs-7 [ Caenorhabditis elegans ]

    Gene ID: 190704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    osm-12
    Official Full Name
    BBSome complex member bbs-7
    Primary source
    WormBase:WBGene00003892
    Locus tag
    CELE_Y75B8A.12
    See related
    AllianceGenome:WB:WBGene00003892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in chemotaxis; cilium organization; and protein localization to microvillus membrane. Located in ciliary basal body; neuron projection; and non-motile cilium. Is expressed in nervous system. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 7. Orthologous to human BBS7 (Bardet-Biedl syndrome 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See osm-12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (12190972..12202537, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene LURY-1-2 Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene titin Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis. Lee EC, et al. PLoS One, 2016. PMID 27111894, Free PMC Article
    2. Identification and characterization of a novel allele of Caenorhabditis elegans bbs-7. Braunreiter K, et al. PLoS One, 2014. PMID 25486278, Free PMC Article
    3. A whole-organism screen identifies new regulators of fat storage. Lemieux GA, et al. Nat Chem Biol, 2011 Apr. PMID 21390037, Free PMC Article
    4. The PKD protein qilin undergoes intraflagellar transport. Ou G, et al. Curr Biol, 2005 Jun 7. PMID 15936258
    5. Caenorhabditis elegans DYF-11, an orthologue of mammalian Traf3ip1/MIP-T3, is required for sensory cilia formation. Kunitomo H, et al. Genes Cells, 2008 Jan. PMID 18173744

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in osm-9 and osm-12 that disrupt amphid neurons-mediated hypertonic avoidance behavior or genetic ablation of amphid neurons are associated with enhanced survival during hypertonic stress.
      Title: Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis.
    2. mutations in the Caenorhabditis elegans bbs-7 gene cause structural and functional defects in cilia
      Title: Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to microvillus membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of BBSome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BBSome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BBSome complex member bbs-7
    NP_499585.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12190972..12202537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067184.3 → NP_499585.1  BBSome complex member bbs-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XW70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XW70.1

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