tdpo-1 Tyrosyl-DNA phosphodiesterase 1;UBC core domain-containing protein;putative tyrosyl-DNA phosphodiesterase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tdpo-1
Official Full Name: Tyrosyl-DNA phosphodiesterase 1;UBC core domain-containing protein;putative tyrosyl-DNA phosphodiesterase
Primary source: WormBase:WBGene00018678
Locus tag: CELE_F52C12.1
See related: AllianceGenome:WB:WBGene00018678
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy 1. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tdpo-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (1959854..1963240)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52C12.1 (e-PCR)
- UniSTS:313161

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'-tyrosyl-DNA phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tyrosyl-DNA phosphodiesterase 1;UBC core domain-containing protein;putative tyrosyl-DNA phosphodiesterase

NP_001368245.1

Confirmed by transcript evidence

NP_001368246.1

Confirmed by transcript evidence

NP_500149.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1959854..1963240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067748.5 → NP_500149.1 putative tyrosyl-DNA phosphodiesterase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500149.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TXV7

Conserved Domains (3) summary

cd09195
Location:215 → 410

PLDc_mTdp1_2; Catalytic domain, repeat 2, of metazoan tyrosyl-DNA phosphodiesterase

pfam06087
Location:36 → 426

Tyr-DNA_phospho; Tyrosyl-DNA phosphodiesterase

cl15239
Location:32 → 194

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
NM_001380071.1 → NP_001368245.1 Tyrosyl-DNA phosphodiesterase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PRC2

Conserved Domains (1) summary

cl15239
Location:82 → 277

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
NM_001380072.1 → NP_001368246.1 UBC core domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PEH4