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    cox-18 Cytochrome OXidase assembly protein [ Caenorhabditis elegans ]

    Gene ID: 176930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cox-18
    Official Full Name
    Cytochrome OXidase assembly protein
    Primary source
    WormBase:WBGene00021932
    Locus tag
    CELE_Y55F3AR.1
    See related
    AllianceGenome:WB:WBGene00021932
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cox-18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (1097453..1102980)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene 8 kDa glycoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Praziquantel inhibits Caenorhabditis elegans development and species-wide differences might be cct-8-dependent. Wit J, et al. PLoS One, 2023. PMID 37561720, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables membrane insertase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables membrane insertase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane from matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome OXidase assembly protein
    NP_500037.2
    • Product from WormBase gene class cox;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1097453..1102980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067636.9 → NP_500037.2  Cytochrome OXidase assembly protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500037.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N356
      Conserved Domains (1) summary
      cl00489
      Location:182 → 282
      60KD_IMP; 60Kd inner membrane protein
    Nucleotide Protein
    Heading Accession and Version

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