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    cpna-2 Copine family protein 2 [ Caenorhabditis elegans ]

    Gene ID: 174250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpna-2
    Official Full Name
    Copine family protein 2
    Primary source
    WormBase:WBGene00015061
    Locus tag
    CELE_B0228.4
    See related
    AllianceGenome:WB:WBGene00015061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be active in nucleus. Is expressed in several structures, including body wall musculature; excretory cell; muscle cell; nervous system; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpna-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    25
    Sequence:
    Chromosome: II; NC_003280.10 (7724903..7752731)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thioredoxin-1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Worms in space? A model biological dosimeter. Zhao Y, et al. Gravit Space Biol Bull, 2005 Jun. PMID 16038089
    2. Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. Huang CR, et al. Nat Commun, 2021 Jan 4. PMID 33397943, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Copine family protein 2
    NP_001021884.1
    • Partially confirmed by transcript evidence
    NP_001040723.1
    • Partially confirmed by transcript evidence
    NP_495623.2
    • Partially confirmed by transcript evidence
    NP_495625.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7724903..7752731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063222.4 → NP_495623.2  Copine family protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495623.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09221
      Conserved Domains (1) summary
      cd01459
      Location:1380 → 1618
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    2. NM_063224.6 → NP_495625.3  Copine family protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495625.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D7SFI9, Q09221, Q10908, Q27GU7, Q5WRU1, Q5WRU2, Q5WRU3
      Conserved Domains (1) summary
      cd01459
      Location:7452 → 7690
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    3. NM_001026713.4 → NP_001021884.1  Copine family protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09221

    4. NM_001047258.3 → NP_001040723.1  Copine family protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09221
      Conserved Domains (1) summary
      cd01459
      Location:2449 → 2687
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09221.4

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