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    mac-1 Protein mac-1 [ Caenorhabditis elegans ]

    Gene ID: 174974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mac-1
    Official Full Name
    Protein mac-1
    Primary source
    WormBase:WBGene00003119
    Locus tag
    CELE_Y48C3A.7
    See related
    AllianceGenome:WB:WBGene00003119
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP hydrolysis activity and preribosome binding activity. Involved in lipid storage; negative regulation of apoptotic process; and positive regulation of nematode larval development. Predicted to be active in nucleus. Is expressed in intestine. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mac-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (13311413..13320911, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine-rich adhesin for platelets;Uncharacterized protein;uncharacterized protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Failed axon connections homolog Neighboring gene Single-stranded DNA-binding protein homolog sam-10 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death. Wu D, et al. Development, 1999 May. PMID 10101135
    2. New insights into apoptosome structure and function. Dorstyn L, et al. Cell Death Differ, 2018 Jul. PMID 29765111, Free PMC Article
    3. C elegans: a model for exploring the genetics of fat storage. McKay RM, et al. Dev Cell, 2003 Jan. PMID 12530969, Free PMC Article
    4. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
    5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables preribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein mac-1
    NP_496814.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13311413..13320911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064413.9 → NP_496814.1  Protein mac-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496814.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAG4, Q9U8K0
      Conserved Domains (2) summary
      pfam16725
      Location:5 → 65
      Nucleolin_bd; Nucleolin binding domain
      cl27568
      Location:191 → 804
      TIP49; TIP49 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NAG4.2

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