toca-1 Transducer of Cdc42-dependent actin assembly protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: toca-1
Official Full Name: Transducer of Cdc42-dependent actin assembly protein 1 homolog
Primary source: WormBase:WBGene00017298
Locus tag: CELE_F09E10.8
See related: AllianceGenome:WB:WBGene00017298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including negative regulation of protein localization to adherens junction; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in cell-cell junction; intracellular vesicle; and plasma membrane. Is expressed in anchor cell and vulF. Orthologous to human FNBP1 (formin binding protein 1); FNBP1L (formin binding protein 1 like); and TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See toca-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (1510481..1521487, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.
Title: toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.
TOCA-1 and TOCA-2 are important for the regulation of Clathrin-mediated endocytic processes during oocyte growth, and in the control of epithelial morphogenesis in developing embryos.
Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F09E10.8 (e-PCR)
- UniSTS:315233

F09E10.9 (e-PCR)
- UniSTS:319225

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic ectodermal digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic ectodermal digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to adherens junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Transducer of Cdc42-dependent actin assembly protein 1 homolog

NP_741723.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1510481..1521487 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171940.8 → NP_741723.1 Transducer of Cdc42-dependent actin assembly protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19253, Q8MQ82

Conserved Domains (3) summary

cd07653
Location:8 → 259

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:362 → 438

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:532 → 586

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4