apr-1 Adenomatous polyposis coli protein;Adenomatous polyposis coli protein-related protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: apr-1
Official Full Name: Adenomatous polyposis coli protein;Adenomatous polyposis coli protein-related protein 1
Primary source: WormBase:WBGene00000156
Locus tag: CELE_K04G2.8
See related: AllianceGenome:WB:WBGene00000156
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; engulfment of apoptotic cell; and regulation of Wnt signaling pathway. Located in adherens junction; cell cortex; and nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and head. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See apr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (8050037..8055475)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle
Title: Tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division.
These results suggest that beta-catenin and APC may regulate asymmetric divisions or Wnt signaling.[APC]
Title: Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans.
The polarity of APR-1 cortical localization is controlled by PRY-1 (C. elegans Axin), such that PRY-1 controls the polarity of both SYS-1 and WRM-1 asymmetries.
Title: The tumor suppressor APC differentially regulates multiple β-catenins through the function of axin and CKIα during C. elegans asymmetric stem cell divisions.
Apoptotic cell clearance and migration of the distal tip cell require the APC/APR-1.
Title: The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04G2.8 (e-PCR)
- UniSTS:317503

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables gamma-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
colocalizes_with cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Adenomatous polyposis coli protein;Adenomatous polyposis coli protein-related protein 1

NP_001021547.1

Confirmed by transcript evidence

NP_001334202.1

Partially confirmed by transcript evidence

NP_492217.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8050037..8055475

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059816.7 → NP_492217.2 Adenomatous polyposis coli protein-related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492217.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21227

Conserved Domains (3) summary

cd00020
Location:312 → 431

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam15912
Location:754 → 896

VIR_N; Virilizer, N-terminal

sd00043
Location:306 → 345

ARM; armadillo repeat [structural motif]
NM_001026376.6 → NP_001021547.1 Adenomatous polyposis coli protein-related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021547.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62302, Q21227

Conserved Domains (3) summary

cd00020
Location:312 → 431

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam15912
Location:756 → 898

VIR_N; Virilizer, N-terminal

sd00043
Location:306 → 345

ARM; armadillo repeat [structural motif]
NM_001347280.1 → NP_001334202.1 Adenomatous polyposis coli protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I6CM53