cdk-11.1 Cyclin-dependent kinase 11.1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdk-11.1
Official Full Name: Cyclin-dependent kinase 11.1
Primary source: WormBase:WBGene00015203
Locus tag: CELE_B0495.2
See related: AllianceGenome:WB:WBGene00015203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in gamete generation and positive regulation of embryonic development. Located in cytoplasm and nucleus. Is expressed in germ line; somatic cell; and somatic gonad. Orthologous to human CDK11A (cyclin dependent kinase 11A) and CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cdk-11.1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (7699235..7702012)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDK-11.1 and CDK-11.2 function redundantly during embryonic and postembryonic development and likely do so in association with Cyclin L.
Title: CDK-11-Cyclin L is required for gametogenesis and fertility in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0495.6 (e-PCR)
- UniSTS:320816

B0495.2 (e-PCR)
- UniSTS:308392

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cyclin-dependent kinase 11.1

NP_001348696.1

Confirmed by transcript evidence

NP_495617.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7699235..7702012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001361863.3 → NP_001348696.1 Cyclin-dependent kinase 11.1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd07843
Location:340 → 637

STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
NM_063216.6 → NP_495617.1 Cyclin-dependent kinase 11.1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495617.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A2K5ATR0, Q09437

Conserved Domains (2) summary

cd07843
Location:350 → 647

STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

PLN00009
Location:353 → 647

PLN00009; cyclin-dependent kinase A; Provisional