plx-1 Sema domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: plx-1
Official Full Name: Sema domain-containing protein
Primary source: WormBase:WBGene00004047
Locus tag: CELE_Y55F3AL.1
See related: AllianceGenome:WB:WBGene00004047
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables semaphorin receptor activity. Involved in epidermis development; nematode male tail mating organ morphogenesis; and nematode male tail tip morphogenesis. Located in ruffle membrane. Is expressed in several structures, including P3.p hermaphrodite; nervous system; non-striated muscle; seam cell; and vulval cell. Orthologous to several human genes including PLXNA1 (plexin A1); PLXNA2 (plexin A2); and PLXNA3 (plexin A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See plx-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 24

Sequence:: Chromosome: IV; NC_003282.8 (959521..984395)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Required for the movement of homologous pairs of vulva cells towards this midline position.
Title: Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline.
PLX-1 suppresses local RAP-2 activity. Excessive ectopic synapse formation in mig-15 mutants causes a severe synaptic tiling defect. Conversely, overexpression of mig-15 strongly inhibited synapse formation, suggesting that mig-15 is a negative regulator of synapse formation.
Title: Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans.
Data show genetically that plexin-1 is part of the same functional pathway as semaphorin-1 and -2 for C. elegans male ray cell positioning.
Title: Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans.
PLX-1, with SMP-1, mediates a cell contact-dependent stop signal in vulval precursor cells.
Title: C. elegans PlexinA PLX-1 mediates a cell contact-dependent stop signal in vulval precursor cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y55F3A_742.a (e-PCR)
- UniSTS:323976

STS4-104 (e-PCR)
- UniSTS:242091

Y55F3B_745.a (e-PCR)
- UniSTS:323757

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail mating organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Sema domain-containing protein

NP_001294554.1

Confirmed by transcript evidence

NP_001294555.1

Confirmed by transcript evidence

NP_001294556.1

Confirmed by transcript evidence

NP_001294557.1

Confirmed by transcript evidence

NP_001294558.1

Confirmed by transcript evidence

NP_500018.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

959521..984395

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067617.6 → NP_500018.3 Sema domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500018.3

Status: REVIEWED

UniProtKB/TrEMBL

G4SL42, Q3V5K0, Q8TA58

Conserved Domains (8) summary

cd11236
Location:42 → 495

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

cd00603
Location:974 → 1059

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01180
Location:878 → 973

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:496 → 550

PSI; Plexin repeat

pfam08337
Location:1333 → 1886

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:557 → 649

TIG_plexin; TIG domain

pfam18020
Location:717 → 822

TIG_2; TIG domain found in plexin

cl15674
Location:1062 → 1146

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001307625.3 → NP_001294554.1 Sema domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294554.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8TA58, U4PRY7

Conserved Domains (8) summary

cd11236
Location:42 → 495

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

cd00603
Location:974 → 1059

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01180
Location:878 → 973

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:496 → 550

PSI; Plexin repeat

pfam08337
Location:1333 → 1897

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:557 → 649

TIG_plexin; TIG domain

pfam18020
Location:717 → 822

TIG_2; TIG domain found in plexin

cl15674
Location:1062 → 1146

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001307626.3 → NP_001294555.1 Sema domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294555.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8TA58, U4PF39

Conserved Domains (8) summary

cd11236
Location:1 → 306

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

cd00603
Location:785 → 870

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01180
Location:689 → 784

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:307 → 361

PSI; Plexin repeat

pfam08337
Location:1144 → 1708

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:368 → 460

TIG_plexin; TIG domain

pfam18020
Location:528 → 633

TIG_2; TIG domain found in plexin

cl15674
Location:873 → 957

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001307627.3 → NP_001294556.1 Sema domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294556.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8TA58, U4PBW0

Conserved Domains (8) summary

cd11236
Location:1 → 306

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

cd00603
Location:785 → 870

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01180
Location:689 → 784

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:307 → 361

PSI; Plexin repeat

pfam08337
Location:1144 → 1697

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:368 → 460

TIG_plexin; TIG domain

pfam18020
Location:528 → 633

TIG_2; TIG domain found in plexin

cl15674
Location:873 → 957

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001307629.3 → NP_001294558.1 Sema domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294558.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PMN2

Conserved Domains (5) summary

cd00603
Location:203 → 288

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01180
Location:107 → 202

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:52 → 105

PSI; Plexin repeat

pfam08337
Location:562 → 1126

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:291 → 375

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001307628.3 → NP_001294557.1 Sema domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294557.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PC90

Conserved Domains (5) summary

cd00603
Location:203 → 288

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01180
Location:107 → 202

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:52 → 105

PSI; Plexin repeat

pfam08337
Location:562 → 1115

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:291 → 375

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...