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    unc-47 Vesicular GABA transporter [ Caenorhabditis elegans ]

    Gene ID: 176431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-47
    Official Full Name
    Vesicular GABA transporter
    Primary source
    WormBase:WBGene00006783
    Locus tag
    CELE_T20G5.6
    See related
    AllianceGenome:WB:WBGene00006783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in gamma-aminobutyric acid transport; glycine transport; and neurotransmitter loading into synaptic vesicle. Located in synaptic vesicle. Is expressed in neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and generalized epilepsy with febrile seizures plus. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-47 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10183762..10186260, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transmembrane cell adhesion receptor mua-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rap guanine nucleotide exchange factor 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coevolution within and between regulatory loci can preserve promoter function despite evolutionary rate acceleration. Barrière A, et al. PLoS Genet, 2012 Sep. PMID 23028368, Free PMC Article
    2. Effect of Euphorbia factor L1 on intestinal barrier impairment and defecation dysfunction in Caenorhabditis elegans. Zhu A, et al. Phytomedicine, 2019 Dec. PMID 31654989
    3. Durations and frequencies of free locomotion in wild type and GABAergic mutants of Caenorhabditis elegans. Shingai R. Neurosci Res, 2000 Sep. PMID 10997580
    4. Growth cones stall and collapse during axon outgrowth in Caenorhabditis elegans. Knobel KM, et al. Development, 1999 Oct. PMID 10498684
    5. The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. Aubrey KR, et al. J Neurosci, 2007 Jun 6. PMID 17554001, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter loading into synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Vesicular GABA transporter
    NP_499255.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10183762..10186260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066854.7 → NP_499255.1  Vesicular GABA transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17475, P34579
      Conserved Domains (2) summary
      COG0814
      Location:90 → 471
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam01490
      Location:88 → 475
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34579.2

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