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    nfki-1 ANK repeat-containing protein nipk-1 [ Caenorhabditis elegans ]

    Gene ID: 181625, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nfki-1
    Official Full Name
    ANK repeat-containing protein nipk-1
    Primary source
    WormBase:WBGene00007877
    Locus tag
    CELE_C33A11.1
    See related
    AllianceGenome:WB:WBGene00007877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in positive regulation of cell differentiation and regulation of transcription by RNA polymerase II. Is expressed in several structures, including nervous system. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nfki-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (15355238..15363861)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Aa_trans domain-containing protein Neighboring gene tRNA Neighboring gene ETS domain-containing protein;Ets-domain protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. Brena D, et al. Sci Rep, 2020 Sep 30. PMID 32999373, Free PMC Article
    2. IL-17: good fear no tears. Rua R, et al. Nat Immunol, 2020 Nov. PMID 32958929
    3. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Chen C, et al. Nature, 2017 Feb 2. PMID 28099418, Free PMC Article
    4. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Flynn SM, et al. Nat Commun, 2020 Apr 29. PMID 32350248, Free PMC Article
    5. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ANK repeat-containing protein nipk-1
    NP_510540.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15355238..15363861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078139.5 → NP_510540.1  ANK repeat-containing protein nipk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDE9
      Conserved Domains (3) summary
      cd00204
      Location:412 → 552
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:375 → 415
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:372 → 447
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDE9.1

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