tsp-17 Tetraspanin-17 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tsp-17
Official Full Name: Tetraspanin-17
Primary source: WormBase:WBGene00006643
Locus tag: CELE_C02F12.1
See related: AllianceGenome:WB:WBGene00006643
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables D2 dopamine receptor binding activity. Involved in cellular response to paraquat; negative regulation of response to oxidative stress; and regulation of dopamine uptake involved in synaptic transmission. Located in several cellular components, including axon; dendrite; and perinuclear region of cytoplasm. Is expressed in several structures, including NSM; body wall musculature; dopaminergic neurons; hermaphrodite gonad; and vulva. Used to study Parkinson's disease and neurodegenerative disease. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human TSPAN3 (tetraspanin 3) and TSPAN7 (tetraspanin 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tsp-17 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (3681164..3684234)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSP-17 protects against neurodegeneration and has a role in modulating behaviors linked to dopamine signaling.
Title: Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C02F12.1 (e-PCR)
- UniSTS:318984

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables D2 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to paraquat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dopamine uptake involved in synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tetraspanin-17

NP_001129920.2

Confirmed by transcript evidence

NP_001300313.1

Confirmed by transcript evidence

NP_001300314.1

Confirmed by transcript evidence

NP_001300315.1

Confirmed by transcript evidence

NP_001370351.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3681164..3684234

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001313384.4 → NP_001300313.1 Tetraspanin-17 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AW84

Conserved Domains (1) summary

pfam00335
Location:11 → 260

Tetraspannin; Tetraspanin family
NM_001383547.2 → NP_001370351.1 Tetraspanin-17 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd03160
Location:112 → 241

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_001136448.4 → NP_001129920.2 Tetraspanin-17 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129920.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AT70, A0A0K3AW84, A0A0K3AYG5, B3WFU6, Q11098

Conserved Domains (2) summary

cd03160
Location:153 → 275

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:11 → 298

Tetraspannin; Tetraspanin family
NM_001313386.3 → NP_001300315.1 Tetraspanin-17 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AT70

Conserved Domains (1) summary

cd03160
Location:30 → 152

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_001313385.3 → NP_001300314.1 Tetraspanin-17 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AYG5

Conserved Domains (1) summary

cl02781
Location:24 → 114

tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...