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    aass-1 Saccharopine dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 176842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aass-1
    Official Full Name
    Saccharopine dehydrogenase
    Primary source
    WormBase:WBGene00019819
    Locus tag
    CELE_R02D3.1
    See related
    AllianceGenome:WB:WBGene00019819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable saccharopine dehydrogenase activity. Predicted to be involved in lysine biosynthetic process via aminoadipic acid. Predicted to be active in cytoplasm. Is expressed in gonadal sheath cell and hypodermal cell. Human ortholog(s) of this gene implicated in hyperlysinemia. Orthologous to human AASS (aminoadipate-semialdehyde synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aass-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (245143..251925)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Neighboring gene Conserved oligomeric Golgi complex subunit 8 Neighboring gene Ground-like domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Exonuclease domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. Zhou J, et al. J Cell Biol, 2019 Feb 4. PMID 30573525, Free PMC Article
    2. A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development. Ponomarova O, et al. PLoS Biol, 2023 Apr. PMID 37043428, Free PMC Article
    3. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
    4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables saccharopine dehydrogenase (NADP+, L-lysine-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables saccharopine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Saccharopine dehydrogenase
    NP_001294658.1
    • Confirmed by transcript evidence
    NP_499884.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      245143..251925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307729.4 → NP_001294658.1  Saccharopine dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PFH6
      Conserved Domains (4) summary
      PLN02819
      Location:28 → 943
      PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
      cd12189
      Location:31 → 489
      LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
      pfam03435
      Location:511 → 626
      Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
      pfam16653
      Location:630 → 942
      Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain

    2. NM_067483.6 → NP_499884.1  Saccharopine dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44503
      Conserved Domains (4) summary
      PLN02819
      Location:28 → 925
      PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
      cd12189
      Location:31 → 471
      LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
      pfam03435
      Location:493 → 608
      Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
      pfam16653
      Location:612 → 924
      Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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