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    catp-8 putative manganese-transporting ATPase catp-8 [ Caenorhabditis elegans ]

    Gene ID: 178070, updated on 9-Dec-2024

    Summary

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    Official Symbol
    catp-8
    Official Full Name
    putative manganese-transporting ATPase catp-8
    Primary source
    WormBase:WBGene00007514
    Locus tag
    CELE_C10C6.6
    See related
    AllianceGenome:WB:WBGene00007514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type ion transporter activity; and protein transporter activity. Acts upstream of with a positive effect on dendrite morphogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including body wall musculature; gonad; intestine; neurons; and pharynx. Orthologous to human ATP13A1 (ATPase 13A1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See catp-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (11473363..11479251, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene ABC transporter domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HTH cro/C1-type domain-containing protein Neighboring gene Non-structural maintenance of chromosomes element 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion. Ramirez-Suarez NJ, et al. Development, 2023 Sep 15. PMID 37721334, Free PMC Article
    2. CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching. Feng Z, et al. Cell Rep, 2020 Sep 8. PMID 32905774
    3. The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning. Tang LTH, et al. PLoS Genet, 2021 Jul. PMID 34197450, Free PMC Article
    4. P5A ATPase controls ER translocation of Wnt in neuronal migration. Li T, et al. Cell Rep, 2021 Oct 26. PMID 34706230
    5. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P5A ATPase controls ER translocation of Wnt in neuronal migration.
      Title: P5A ATPase controls ER translocation of Wnt in neuronal migration.
    2. The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.
      Title: The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type ion transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative manganese-transporting ATPase catp-8
    NP_502165.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11473363..11479251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069764.6 → NP_502165.2  putative manganese-transporting ATPase catp-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502165.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02620, P90747
      Conserved Domains (4) summary
      COG4087
      Location:793 → 842
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:37 → 1153
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:251 → 380
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:532 → 613
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90747.3

    Gene LinkOut

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