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    nrx-1 Neurexin-3-beta [ Caenorhabditis elegans ]

    Gene ID: 179503, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nrx-1
    Official Full Name
    Neurexin-3-beta
    Primary source
    WormBase:WBGene00007799
    Locus tag
    CELE_C29A12.4
    See related
    AllianceGenome:WB:WBGene00007799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of receptor clustering. Located in presynaptic active zone. Is expressed in nervous system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2 and alcohol dependence. Orthologous to several human genes including NRXN1 (neurexin 1) and NRXN3 (neurexin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nrx-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    30
    Sequence:
    Chromosome: V; NC_003283.11 (10825011..10846703)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene Suppressor of activated egl-4 protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurexin drives Caenorhabditis elegans avoidance behavior independently of its post-synaptic binding partner neuroligin. Muirhead CS, et al. G3 (Bethesda), 2024 Aug 7. PMID 38781440, Free PMC Article
    2. Neurexin controls plasticity of a mature, sexually dimorphic neuron. Hart MP, et al. Nature, 2018 Jan 10. PMID 29323291, Free PMC Article
    3. Neurexin directs partner-specific synaptic connectivity in C. elegans. Philbrook A, et al. Elife, 2018 Jul 24. PMID 30039797, Free PMC Article
    4. Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components. Oliver D, et al. PLoS Genet, 2022 Jan. PMID 35089924, Free PMC Article
    5. Directional Trans-Synaptic Labeling of Specific Neuronal Connections in Live Animals. Desbois M, et al. Genetics, 2015 Jul. PMID 25917682, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components.
      Title: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components.
    2. Starvation-induced remodeling is also dependent on neuroligin/nlg-1, the canonical binding partner for neurexin/nrx-1, and the transcription factors FOXO/daf-16 and HSF1/hsf-1 hsf-1 and daf-16.
      Title: Stress-Induced Neuron Remodeling Reveals Differential Interplay Between Neurexin and Environmental Factors in Caenorhabditis elegans.
    3. neurexin controls plasticity of a mature, sexually dimorphic neuron
      Title: Neurexin controls plasticity of a mature, sexually dimorphic neuron.
    4. study found neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions
      Title: Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in negative regulation of receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Neurexin-3-beta
    NP_001122868.2
    • Confirmed by transcript evidence
    NP_001256262.1
    • Confirmed by transcript evidence
    NP_001256263.1
    • Confirmed by transcript evidence
    NP_001256264.1
    • Confirmed by transcript evidence
    NP_001256265.1
    • Confirmed by transcript evidence
    NP_001256266.1
    • Confirmed by transcript evidence
    NP_001256267.1
    • Confirmed by transcript evidence
    NP_001256268.1
    • Confirmed by transcript evidence
    NP_001256270.1
    • Confirmed by transcript evidence
    NP_001263859.1
    • Confirmed by transcript evidence
    NP_001263860.1
    • Confirmed by transcript evidence
    NP_001294674.1
    • Confirmed by transcript evidence
    NP_001364673.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10825011..10846703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269333.4 → NP_001256262.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256262.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18291, Q18294
      Conserved Domains (3) summary
      cd00054
      Location:654 → 689
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:468 → 625
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:1129 → 1265
      Laminin_G_2; Laminin G domain

    2. NM_001129396.5 → NP_001122868.2  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122868.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7UQ09
      Conserved Domains (3) summary
      cd00054
      Location:654 → 689
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:468 → 625
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:1129 → 1265
      Laminin_G_2; Laminin G domain

    3. NM_001276930.3 → NP_001263859.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAJ6
      Conserved Domains (3) summary
      cd00054
      Location:663 → 698
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:477 → 634
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:1138 → 1274
      Laminin_G_2; Laminin G domain

    4. NM_001276931.3 → NP_001263860.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAJ7
      Conserved Domains (3) summary
      cd00054
      Location:663 → 698
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:477 → 634
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:1138 → 1274
      Laminin_G_2; Laminin G domain

    5. NM_001269334.3 → NP_001256263.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6S5

    6. NM_001269335.3 → NP_001256264.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6S6

    7. NM_001307745.4 → NP_001294674.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZT1

    8. NM_001269336.2 → NP_001256265.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P874

    9. NM_001269337.3 → NP_001256266.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLH5

    10. NM_001269338.1 → NP_001256267.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P875

    11. NM_001269339.3 → NP_001256268.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ40

    12. NM_001377602.2 → NP_001364673.1  Neurexin-3-beta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P876

    13. NM_001269341.3 → NP_001256270.1  Neurexin-3-beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6S7
    Nucleotide Protein
    Heading Accession and Version

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