dnj-1 DnaJ homolog subfamily B member 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dnj-1
Official Full Name: DnaJ homolog subfamily B member 1
Primary source: WormBase:WBGene00001019
Locus tag: CELE_B0035.14
See related: AllianceGenome:WB:WBGene00001019
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Hsp70 protein binding activity. Involved in protein-containing complex assembly. Located in endoplasmic reticulum membrane. Is expressed in neurons and vulval muscle. Orthologous to several human genes including DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12) and DNAJB14 (DnaJ heat shock protein family (Hsp40) member B14). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dnj-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (11299036..11304788)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG K+ channels. They regulate two distinct aspects of K+ channel biogenesis, the stabilization and assembly of channel subunits.
Title: Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0035.14 (e-PCR)
- UniSTS:313008

B0035.15 (e-PCR)
- UniSTS:307174

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to misfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DnaJ homolog subfamily B member 1

NP_001263785.1

Partially confirmed by transcript evidence

NP_502122.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11299036..11304788

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069721.8 → NP_502122.1 DnaJ homolog subfamily B member 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502122.1

Status: REVIEWED

UniProtKB/Swiss-Prot

K8ESE7, Q17438

Conserved Domains (2) summary

pfam09320
Location:300 → 397

DUF1977; Domain of unknown function (DUF1977)

cl28246
Location:137 → 260

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
NM_001276856.3 → NP_001263785.1 DnaJ homolog subfamily B member 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263785.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17438

Conserved Domains (1) summary

pfam09320
Location:1 → 42

DUF1977; Domain of unknown function (DUF1977)